POLR3H

RNA polymerase III subunit H | C25, KIAA1665, RPC8

Enables DNA-directed RNA polymerase activity. Involved in transcription by RNA polymerase III. Located in centrosome and nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-6 DE-6.17

Biological processes 20 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase complex (GO:0000428)DNA-templated transcription (GO:0006351)DNA-templated transcription initiation (GO:0006352)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)centrosome (GO:0005813)cytosol (GO:0005829)nucleobase-containing compound metabolic process (GO:0006139)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase III (GO:0006383)transcription initiation at RNA polymerase III promoter (GO:0006384)transcription initiation at RNA polymerase III promoter (GO:0006384)

Expression (TPM)

TFs regulating POLR3H 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR3H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR3H

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,285,539–41,286,833	258.1 kb	Distal (>10kb) Multiome	879
chr22:41,301,155–41,301,870	243.0 kb	Distal (>10kb) Multiome	658
chr22:41,380,458–41,382,737	162.8 kb	Distal (>10kb) Multiome	925
chr22:41,413,486–41,414,305	130.6 kb	Distal (>10kb) Multiome	832
chr22:41,444,084–41,445,743	99.9 kb	Distal (>10kb) Multiome	607
chr22:41,446,165–41,449,007	97.6 kb	Distal (>10kb) Multiome	1188
chr22:41,468,341–41,469,602	75.6 kb	Distal (>10kb) Multiome	920
chr22:41,512,659–41,513,151	31.5 kb	Distal (>10kb) Multiome	354
chr22:41,543,855–41,544,782	68 bp	At TSS Multiome	755
chr22:41,589,188–41,590,530	45.5 kb	Distal (>10kb) Multiome	758
chr22:41,620,173–41,622,049	76.6 kb	Distal (>10kb) Multiome	880
chr22:41,666,496–41,667,405	122.4 kb	Distal (>10kb) Multiome	725
chr22:41,697,169–41,697,792	152.9 kb	Distal (>10kb) Multiome	464
chr22:41,800,274–41,801,345	256.1 kb	Distal (>10kb) Multiome	816
chr22:41,832,291–41,834,215	288.4 kb	Distal (>10kb) Multiome	1023

Genome Browser

Genomic view of the POLR3H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.