POLE4

DNA polymerase epsilon 4, accessory subunit | p12

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

Member of: DE-1

Biological processes 14 terms

ATAC complex (GO:0140672)DNA biosynthetic process (GO:0071897)DNA-directed DNA polymerase activity (GO:0003887)DNA-templated DNA replication (GO:0006261)DNA-templated DNA replication (GO:0006261)epsilon DNA polymerase complex (GO:0008622)epsilon DNA polymerase complex (GO:0008622)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)

Expression (TPM)

TFs regulating POLE4 0 TFs

Transcription factors with Perturb-seq knockdown data for POLE4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLE4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLE4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLE4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:74,715,073–74,715,890	243.3 kb	Distal (>10kb) Multiome	768
chr2:74,777,656–74,779,073	180.0 kb	Distal (>10kb) Multiome	426
chr2:74,816,374–74,817,201	141.8 kb	Distal (>10kb) Multiome	373
chr2:74,822,732–74,823,334	135.7 kb	Distal (>10kb) Multiome	40
chr2:74,833,573–74,835,838	123.3 kb	Distal (>10kb) Multiome	968
chr2:74,919,661–74,920,281	38.6 kb	Distal (>10kb) Multiome	376
chr2:74,958,221–74,959,258	110 bp	At TSS Multiome	1096
chr2:75,055,603–75,056,664	97.7 kb	Distal (>10kb) Multiome	263
chr2:75,153,714–75,154,360	195.6 kb	Distal (>10kb) Multiome	222
chr2:75,199,295–75,200,926	242.0 kb	Distal (>10kb) Multiome	391

Genome Browser

Genomic view of the POLE4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.