POLDIP3

DNA polymerase delta interacting protein 3 | KIAA1649, PDIP3, PDIP46, SKAR

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Biological processes 21 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic ribonucleoprotein granule (GO:0036464)cytosol (GO:0005829)mRNA binding (GO:0003729)mRNA export from nucleus (GO:0006406)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)poly(A)+ mRNA export from nucleus (GO:0016973)poly(A)+ mRNA export from nucleus (GO:0016973)poly(A)+ mRNA export from nucleus (GO:0016973)positive regulation of translation (GO:0045727)protein binding (GO:0005515)protein-containing complex binding (GO:0044877)

Expression (TPM)

TFs regulating POLDIP3 0 TFs

Transcription factors with Perturb-seq knockdown data for POLDIP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLDIP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLDIP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLDIP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:42,343,251–42,344,201	271.3 kb	Distal (>10kb) Multiome	220
chr22:42,344,438–42,344,933	270.1 kb	Distal (>10kb) Multiome	162
chr22:42,365,301–42,366,142	249.3 kb	Distal (>10kb) Multiome	197
chr22:42,368,263–42,369,908	245.6 kb	Distal (>10kb) Multiome	592
chr22:42,437,555–42,438,618	177.1 kb	Distal (>10kb) Multiome	501
chr22:42,444,134–42,444,723	170.5 kb	Distal (>10kb) Multiome	574
chr22:42,499,840–42,501,072	114.4 kb	Distal (>10kb) Multiome	356
chr22:42,519,544–42,520,134	95.1 kb	Distal (>10kb) Multiome	330
chr22:42,553,476–42,554,267	61.0 kb	Distal (>10kb) Multiome	514
chr22:42,581,750–42,582,381	32.8 kb	Distal (>10kb) Multiome	290
chr22:42,614,291–42,616,423	468 bp	At TSS Multiome	1280
chr22:42,621,613–42,621,937	6.7 kb	Proximal (<10kb)	331
chr22:42,648,972–42,649,906	34.6 kb	Distal (>10kb) Multiome	625
chr22:42,662,035–42,662,743	47.4 kb	Distal (>10kb) Multiome	468
chr22:42,720,289–42,721,050	105.9 kb	Distal (>10kb) Multiome	297
chr22:42,800,630–42,801,305	186.1 kb	Distal (>10kb) Multiome	559
chr22:42,856,601–42,857,716	242.4 kb	Distal (>10kb) Multiome	938
chr22:43,923,130–43,924,772	1308.9 kb	Distal (>10kb) Multiome HiCAR	741

Genome Browser

Genomic view of the POLDIP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.