This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for POLD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,147,523–50,148,432 | 236.2 kb | Distal (>10kb) Multiome | 615 | |
| chr19:50,203,034–50,204,072 | 180.8 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 178.9 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 72.1 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 70.1 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 68.3 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 58.5 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 55.0 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 53.4 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 50.8 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 15.4 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 7.7 kb | Proximal (<10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 102 bp | At TSS Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 30.6 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 47.5 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 92.2 kb | Distal (>10kb) Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 127.0 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 172.4 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 255.4 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 273.9 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the POLD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.