Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POGLUT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POGLUT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POGLUT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:108,221,947–108,224,257 | 275.5 kb | Distal (>10kb) Multiome | 939 | |
| chr11:108,467,108–108,468,105 | 30.9 kb | Distal (>10kb) Multiome | 756 | |
| chr11:108,486,866–108,487,492 | at TSS | At TSS | 18 | |
| chr11:108,497,307–108,498,913 | 524 bp | At TSS Multiome | 959 | |
| chr11:108,499,227–108,499,642 | 861 bp | At TSS | 49 | |
| chr11:108,592,726–108,594,399 | 95.4 kb | Distal (>10kb) Multiome | 684 | |
| chr11:108,664,315–108,665,549 | 166.6 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the POGLUT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.