This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for PODXL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PODXL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PODXL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:127,411,192–127,411,666 | 217.7 kb | Distal (>10kb) Multiome | 109 | |
| chr3:127,455,528–127,456,092 | 173.5 kb | Distal (>10kb) Multiome | 441 | |
| chr3:127,544,147–127,544,731 | 84.8 kb | Distal (>10kb) Multiome | 252 | |
| chr3:127,547,261–127,548,296 | 81.3 kb | Distal (>10kb) Multiome | 460 | |
| chr3:127,589,888–127,591,601 | 38.3 kb | Distal (>10kb) Multiome | 860 | |
| chr3:127,597,808–127,598,722 | 30.9 kb | Distal (>10kb) Multiome | 825 | |
| chr3:127,628,865–127,629,778 | 45 bp | At TSS Multiome | 643 | |
| chr3:127,672,199–127,673,619 | 43.8 kb | Distal (>10kb) Multiome | 714 | |
| chr3:127,732,310–127,732,974 | 103.3 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the PODXL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.