The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for PNMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,400,997–39,402,766 | 266.3 kb | Distal (>10kb) Multiome | 898 | |
| chr17:39,450,919–39,451,504 | 216.7 kb | Distal (>10kb) Multiome | 722 | |
| chr17:39,461,043–39,462,217 | 206.5 kb | Distal (>10kb) Multiome | 1026 | |
| chr17:39,573,453–39,574,243 | 94.2 kb | Distal (>10kb) Multiome | 520 | |
| chr17:39,636,769–39,637,600 | 30.8 kb | Distal (>10kb) Multiome | 853 | |
| chr17:39,668,234–39,668,690 | 498 bp | At TSS Multiome | 706 | |
| chr17:39,687,710–39,688,437 | 20.0 kb | Distal (>10kb) Multiome | 800 | |
| chr17:39,695,905–39,696,636 | 28.3 kb | Distal (>10kb) Multiome | 499 | |
| chr17:39,730,039–39,730,906 | 62.5 kb | Distal (>10kb) Multiome | 886 | |
| chr17:39,740,384–39,740,910 | 72.8 kb | Distal (>10kb) Multiome | 513 | |
| chr17:39,753,811–39,754,996 | 86.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr17:39,926,716–39,928,343 | 259.7 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 285.2 kb | Distal (>10kb) Multiome | 598 |
Genomic view of the PNMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.