The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PLPPR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPPR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPPR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:530,809–533,397 | 290.5 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 249.5 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 233.6 kb | Distal (>10kb) Multiome | 526 | |
| chr19:632,653–633,806 | 188.3 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 182.2 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 158.6 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 141.2 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 117.9 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 113.1 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 24.7 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 189 bp | At TSS Multiome | 254 | |
| chr19:861,664–863,223 | 40.3 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 71.3 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 95.9 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 103.7 kb | Distal (>10kb) Multiome | 796 | |
| chr19:927,058–927,629 | 105.4 kb | Distal (>10kb) Multiome | 362 | |
| chr19:982,565–983,215 | 160.9 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 162.5 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,000,142–1,000,881 | 178.4 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 199.4 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 204.5 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 206.6 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 218.0 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 219.2 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 223.4 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 240.6 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 242.9 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 245.3 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 249.2 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 260.5 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 273.5 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 282.0 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 290.4 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 291.6 kb | Distal (>10kb) Multiome | 690 |
Genomic view of the PLPPR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.