Enables isoprenoid diphosphate phosphatase activity and phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Located in endoplasmic reticulum membrane and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLPP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:2,843,166–2,844,741 | 1818.1 kb | Distal (>10kb) Multiome HiCAR | 860 | |
| chr9:4,489,445–4,492,426 | 170.5 kb | Distal (>10kb) Multiome | 545 | |
| chr9:4,507,563–4,508,683 | 154.0 kb | Distal (>10kb) Multiome | 213 | |
| chr9:4,514,255–4,515,200 | 147.4 kb | Distal (>10kb) Multiome | 105 | |
| chr9:4,661,662–4,663,256 | 32 bp | At TSS Multiome | 925 | |
| chr9:4,666,059–4,666,664 | 3.8 kb | Proximal (<10kb) | 454 | |
| chr9:4,678,800–4,680,345 | 17.3 kb | Distal (>10kb) Multiome | 960 | |
| chr9:4,740,523–4,742,116 | 79.0 kb | Distal (>10kb) Multiome | 942 | |
| chr9:4,762,590–4,763,629 | 101.1 kb | Distal (>10kb) Multiome | 504 | |
| chr9:4,792,132–4,794,058 | 130.5 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the PLPP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.