Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLGRKT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLGRKT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLGRKT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:4,740,523–4,742,116 | 696.6 kb | Distal (>10kb) Multiome HiCAR | 942 | |
| chr9:4,762,590–4,763,629 | 674.5 kb | Distal (>10kb) Multiome HiCAR | 504 | |
| chr9:5,326,958–5,327,775 | 110.5 kb | Distal (>10kb) Multiome | 145 | |
| chr9:5,437,323–5,438,772 | 7 bp | At TSS Multiome | 858 | |
| chr9:5,438,878–5,439,257 | 1.0 kb | Proximal (<10kb) | 128 | |
| chr9:5,442,483–5,442,689 | 4.6 kb | Proximal (<10kb) | 114 | |
| chr9:5,450,352–5,451,061 | 12.7 kb | Distal (>10kb) Multiome | 726 | |
| chr9:5,484,921–5,486,234 | 47.7 kb | Distal (>10kb) Multiome | 123 | |
| chr9:5,628,133–5,629,918 | 191.0 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the PLGRKT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.