Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and cytosol. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHJ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHJ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHJ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,940,240–1,942,987 | 295.3 kb | Distal (>10kb) Multiome | 901 | |
| chr19:2,034,637–2,035,967 | 201.2 kb | Distal (>10kb) Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 194.1 kb | Distal (>10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 185.0 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 174.7 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 139.6 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 84.6 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 72.4 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 316 bp | At TSS Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 33.1 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 37.5 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 92.3 kb | Distal (>10kb) Multiome | 759 | |
| chr19:2,424,712–2,426,099 | 189.0 kb | Distal (>10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 191.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 220.7 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 225.8 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 226.9 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 239.8 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 243.1 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 253.0 kb | Distal (>10kb) Multiome | 276 |
Genomic view of the PLEKHJ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.