Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,387,693–42,389,289 | 288.4 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,422,618–42,423,513 | 253.7 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,535,863–42,536,855 | 140.6 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 128.6 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 122.2 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 114.9 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 109.9 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 99.2 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 98.3 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 67.5 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 17.7 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 6.3 kb | Proximal (<10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 3.0 kb | Proximal (<10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 1.8 kb | Proximal (<10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 1.4 kb | Proximal (<10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 3.0 kb | Proximal (<10kb) Multiome | 654 | |
| chr17:42,681,360–42,681,672 | 4.4 kb | Proximal (<10kb) | 170 | |
| chr17:42,682,428–42,682,628 | 5.4 kb | Proximal (<10kb) | 491 | |
| chr17:42,682,736–42,683,400 | 5.8 kb | Proximal (<10kb) Multiome | 480 | |
| chr17:42,744,352–42,745,375 | 67.9 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 84.0 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 103.5 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 121.7 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 147.3 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 156.3 kb | Distal (>10kb) Multiome | 980 | |
| chr17:42,964,237–42,964,843 | 287.5 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the PLEKHH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.