Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,894,252–94,897,051 | 238.3 kb | Distal (>10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 184.3 kb | Distal (>10kb) Multiome | 850 | |
| chr8:95,024,342–95,025,424 | 108.8 kb | Distal (>10kb) Multiome | 980 | |
| chr8:95,132,764–95,134,804 | 55 bp | At TSS Multiome | 917 | |
| chr8:95,268,225–95,270,513 | 136.0 kb | Distal (>10kb) Multiome | 1069 | |
| chr8:95,430,278–95,431,301 | 297.1 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the PLEKHF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.