Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in endosome and lysosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:29,528,180–29,529,621 | 136.9 kb | Distal (>10kb) Multiome | 401 | |
| chr19:29,529,766–29,530,718 | 135.1 kb | Distal (>10kb) Multiome | 175 | |
| chr19:29,605,720–29,606,615 | 59.3 kb | Distal (>10kb) Multiome | 901 | |
| chr19:29,610,433–29,610,904 | 54.8 kb | Distal (>10kb) Multiome | 320 | |
| chr19:29,665,021–29,667,200 | 1.3 kb | Proximal (<10kb) Multiome | 621 | |
| chr19:29,714,800–29,715,683 | 49.8 kb | Distal (>10kb) Multiome | 726 | |
| chr19:29,724,045–29,724,626 | 58.9 kb | Distal (>10kb) Multiome | 189 | |
| chr19:29,759,946–29,760,434 | 94.8 kb | Distal (>10kb) Multiome | 502 | |
| chr19:29,811,175–29,812,847 | 146.3 kb | Distal (>10kb) Multiome | 705 | |
| chr19:29,843,949–29,845,909 | 179.5 kb | Distal (>10kb) Multiome | 804 | |
| chr19:29,872,961–29,874,087 | 208.2 kb | Distal (>10kb) Multiome | 469 | |
| chr19:29,941,860–29,942,984 | 276.9 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the PLEKHF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.