PLEK
pleckstrin | P47, PLEK1

Enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of actin filament organization; and regulation of phosphate metabolic process. Located in cytoplasm and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Biological processes 47 terms
actin cytoskeleton organization (GO:0030036)actin cytoskeleton organization (GO:0030036)cell projection organization (GO:0030030)cortical actin cytoskeleton organization (GO:0030866)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular region (GO:0005576)hematopoietic progenitor cell differentiation (GO:0002244)inositol phosphate metabolic process (GO:0043647)integrin-mediated signaling pathway (GO:0007229)intracellular signal transduction (GO:0035556)membrane (GO:0016020)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)negative regulation of calcium-mediated signaling (GO:0050849)negative regulation of inositol phosphate biosynthetic process (GO:0010920)negative regulation of thrombin-activated receptor signaling pathway (GO:0070495)phosphatase activator activity (GO:0019211)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)phospholipase C-inhibiting G protein-coupled receptor signaling pathway (GO:0030845)plasma membrane (GO:0005886)platelet aggregation (GO:0070527)platelet aggregation (GO:0070527)platelet aggregation (GO:0070527)platelet degranulation (GO:0002576)platelet degranulation (GO:0002576)positive regulation of actin filament bundle assembly (GO:0032233)positive regulation of actin filament depolymerization (GO:0030836)positive regulation of actin filament depolymerization (GO:0030836)positive regulation of cellular component biogenesis (GO:0044089)positive regulation of integrin activation (GO:0033625)positive regulation of integrin activation (GO:0033625)positive regulation of platelet activation (GO:0010572)positive regulation of platelet activation (GO:0010572)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase C binding (GO:0005080)protein secretion by platelet (GO:0070560)protein secretion by platelet (GO:0070560)regulation of cell diameter (GO:0060305)ruffle membrane (GO:0032587)ruffle organization (GO:0031529)thrombin-activated receptor signaling pathway (GO:0070493)thrombin-activated receptor signaling pathway (GO:0070493)vesicle docking involved in exocytosis (GO:0006904)vesicle docking involved in exocytosis (GO:0006904)
Expression (TPM)
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