Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLAC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:79,904,553–79,905,313 | 227.8 kb | Distal (>10kb) Multiome | 317 | |
| chr10:79,981,449–79,982,593 | 150.8 kb | Distal (>10kb) Multiome | 420 | |
| chr10:80,078,334–80,079,521 | 53.8 kb | Distal (>10kb) Multiome | 806 | |
| chr10:80,131,482–80,131,960 | 629 bp | At TSS | 22 | |
| chr10:80,132,279–80,133,011 | 96 bp | At TSS Multiome | 155 | |
| chr10:80,204,736–80,206,157 | 72.8 kb | Distal (>10kb) Multiome | 830 | |
| chr10:80,207,076–80,207,999 | 74.8 kb | Distal (>10kb) Multiome | 466 | |
| chr10:80,265,707–80,266,498 | 133.4 kb | Distal (>10kb) Multiome | 166 | |
| chr10:80,356,265–80,357,947 | 224.2 kb | Distal (>10kb) Multiome | 316 | |
| chr10:80,407,698–80,409,441 | 275.8 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the PLAC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.