Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PLAA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:26,682,826–26,683,655 | 264.0 kb | Distal (>10kb) Multiome | 130 | |
| chr9:26,891,915–26,893,136 | 54.6 kb | Distal (>10kb) Multiome | 980 | |
| chr9:26,946,640–26,948,029 | 43 bp | At TSS Multiome | 852 | |
| chr9:26,955,897–26,957,142 | 9.2 kb | Proximal (<10kb) Multiome | 646 | |
| chr9:26,974,839–26,976,887 | 29.1 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the PLAA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.