The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for PLA2G7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2G7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2G7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:46,490,464–46,492,348 | 244.3 kb | Distal (>10kb) Multiome | 545 | |
| chr6:46,652,280–46,653,567 | 82.8 kb | Distal (>10kb) Multiome | 662 | |
| chr6:46,733,963–46,735,949 | 1.4 kb | Proximal (<10kb) Multiome | 489 | |
| chr6:46,749,672–46,750,206 | 14.2 kb | Distal (>10kb) Multiome | 168 | |
| chr6:46,848,790–46,849,672 | 113.4 kb | Distal (>10kb) Multiome | 504 |
Genomic view of the PLA2G7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.