PLA2G4B
phospholipase A2 group IVB | HsT16992, cPLA2-beta

This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]

Biological processes 37 terms
A2-type glycerophospholipase activity (GO:0004623)A2-type glycerophospholipase activity (GO:0004623)A2-type glycerophospholipase activity (GO:0004623)A2-type glycerophospholipase activity (GO:0004623)arachidonate metabolic process (GO:0019369)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)calcium-dependent phospholipid binding (GO:0005544)calcium-dependent phospholipid binding (GO:0005544)calcium-mediated signaling (GO:0019722)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)early endosome membrane (GO:0031901)early endosome membrane (GO:0031901)extracellular region (GO:0005576)glycerophospholipase activity (GO:0004620)glycerophospholipid catabolic process (GO:0046475)glycerophospholipid catabolic process (GO:0046475)glycerophospholipid metabolic process (GO:0006650)glycerophospholipid phospholipase A1 activity (GO:0008970)glycerophospholipid phospholipase A1 activity (GO:0008970)glycerophospholipid phospholipase A1 activity (GO:0008970)inflammatory response (GO:0006954)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)parturition (GO:0007567)phosphatidylcholine acyl-chain remodeling (GO:0036151)phosphatidylcholine lysophospholipase A1 activity (GO:0004622)phosphatidylcholine lysophospholipase A1 activity (GO:0004622)phosphatidylcholine lysophospholipase A1 activity (GO:0004622)phosphatidylethanolamine acyl-chain remodeling (GO:0036152)phosphatidylglycerol acyl-chain remodeling (GO:0036148)phospholipid catabolic process (GO:0009395)
Expression (TPM)