Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PLA2G12A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2G12A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2G12A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,433,232–109,434,512 | 296.4 kb | Distal (>10kb) Multiome | 802 | |
| chr4:109,559,632–109,561,390 | 169.9 kb | Distal (>10kb) Multiome | 756 | |
| chr4:109,701,412–109,703,899 | 26.7 kb | Distal (>10kb) Multiome | 799 | |
| chr4:109,729,247–109,730,761 | 2 bp | At TSS Multiome | 793 | |
| chr4:109,814,867–109,816,081 | 85.4 kb | Distal (>10kb) Multiome | 846 | |
| chr4:109,846,257–109,847,050 | 116.6 kb | Distal (>10kb) Multiome | 131 | |
| chr4:109,928,231–109,928,964 | 198.5 kb | Distal (>10kb) Multiome | 114 |
Genomic view of the PLA2G12A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.