Transcription factors with Perturb-seq knockdown data for PKD2L2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PKD2L2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PKD2L2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:137,735,317–137,736,260 | 153.4 kb | Distal (>10kb) Multiome | 301 | |
| chr5:137,753,755–137,755,355 | 134.8 kb | Distal (>10kb) Multiome | 1048 | |
| chr5:137,889,233–137,889,561 | at TSS | At TSS | 497 | |
| chr5:138,032,174–138,033,856 | 143.7 kb | Distal (>10kb) Multiome | 889 | |
| chr5:138,036,018–138,036,514 | 146.8 kb | Distal (>10kb) Multiome | 359 | |
| chr5:138,178,349–138,179,428 | 289.5 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the PKD2L2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.