PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

Biological processes 71 terms
1-phosphatidylinositol-3-kinase activity (GO:0016303)1-phosphatidylinositol-3-kinase activity (GO:0016303)1-phosphatidylinositol-3-kinase activity (GO:0016303)1-phosphatidylinositol-3-kinase activity (GO:0016303)1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)T cell activation (GO:0042110)T cell chemotaxis (GO:0010818)T cell proliferation (GO:0042098)adaptive immune response (GO:0002250)cell migration (GO:0016477)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)dendritic cell chemotaxis (GO:0002407)ephrin receptor binding (GO:0046875)identical protein binding (GO:0042802)immune response (GO:0006955)inflammatory response (GO:0006954)innate immune response (GO:0045087)kinase activity (GO:0016301)mast cell degranulation (GO:0043303)membrane (GO:0016020)membrane (GO:0016020)natural killer cell chemotaxis (GO:0035747)negative regulation of cardiac muscle contraction (GO:0055118)neutrophil chemotaxis (GO:0030593)neutrophil extravasation (GO:0072672)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase complex, class IB (GO:0005944)phosphatidylinositol 3-kinase complex, class IB (GO:0005944)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol phosphate biosynthetic process (GO:0046854)phosphatidylinositol phosphate biosynthetic process (GO:0046854)phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)phosphatidylinositol-mediated signaling (GO:0048015)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)platelet aggregation (GO:0070527)positive regulation of MAP kinase activity (GO:0043406)positive regulation of Rac protein signal transduction (GO:0035022)positive regulation of Rac protein signal transduction (GO:0035022)positive regulation of cytokine production (GO:0001819)positive regulation of endothelial cell migration (GO:0010595)positive regulation of endothelial cell migration (GO:0010595)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)regulation of angiogenesis (GO:0045765)regulation of cell adhesion mediated by integrin (GO:0033628)respiratory burst involved in defense response (GO:0002679)sphingosine-1-phosphate receptor signaling pathway (GO:0003376)sphingosine-1-phosphate receptor signaling pathway (GO:0003376)
Expression (TPM)
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