Transcription factors with Perturb-seq knockdown data for PIK3CD-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3CD-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3CD-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,428,560–9,429,575 | 258.6 kb | Distal (>10kb) Multiome | 815 | |
| chr1:9,495,048–9,495,686 | 192.2 kb | Distal (>10kb) Multiome | 606 | |
| chr1:9,538,797–9,540,343 | 148.2 kb | Distal (>10kb) Multiome | 879 | |
| chr1:9,588,272–9,589,797 | 98.9 kb | Distal (>10kb) Multiome | 633 | |
| chr1:9,593,403–9,593,904 | 94.0 kb | Distal (>10kb) Multiome | 326 | |
| chr1:9,627,002–9,627,511 | 60.4 kb | Distal (>10kb) Multiome | 773 | |
| chr1:9,651,631–9,652,549 | 35.5 kb | Distal (>10kb) Multiome | 373 | |
| chr1:9,687,158–9,688,089 | 40 bp | At TSS Multiome | 575 | |
| chr1:9,688,950–9,690,301 | 2.0 kb | Proximal (<10kb) Multiome | 585 | |
| chr1:9,823,213–9,824,739 | 136.5 kb | Distal (>10kb) Multiome | 652 | |
| chr1:9,874,956–9,875,558 | 187.5 kb | Distal (>10kb) Multiome | 397 | |
| chr1:9,909,556–9,911,240 | 222.9 kb | Distal (>10kb) Multiome | 791 | |
| chr1:9,942,849–9,943,619 | 255.7 kb | Distal (>10kb) Multiome | 1015 |
Genomic view of the PIK3CD-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.