Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for PIK3CD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3CD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3CD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,428,560–9,429,575 | 260.6 kb | Distal (>10kb) Multiome | 815 | |
| chr1:9,495,048–9,495,686 | 194.2 kb | Distal (>10kb) Multiome | 606 | |
| chr1:9,538,797–9,540,343 | 150.2 kb | Distal (>10kb) Multiome | 879 | |
| chr1:9,588,272–9,589,797 | 100.8 kb | Distal (>10kb) Multiome | 633 | |
| chr1:9,593,403–9,593,904 | 95.9 kb | Distal (>10kb) Multiome | 326 | |
| chr1:9,627,002–9,627,511 | 62.4 kb | Distal (>10kb) Multiome | 773 | |
| chr1:9,651,631–9,652,549 | 37.5 kb | Distal (>10kb) Multiome | 373 | |
| chr1:9,687,158–9,688,089 | 1.9 kb | Proximal (<10kb) Multiome | 575 | |
| chr1:9,688,950–9,690,301 | 13 bp | At TSS Multiome | 585 | |
| chr1:9,823,213–9,824,739 | 134.5 kb | Distal (>10kb) Multiome | 652 | |
| chr1:9,874,956–9,875,558 | 185.6 kb | Distal (>10kb) Multiome | 397 | |
| chr1:9,909,556–9,911,240 | 220.9 kb | Distal (>10kb) Multiome | 791 | |
| chr1:9,942,849–9,943,619 | 253.8 kb | Distal (>10kb) Multiome | 1015 |
Genomic view of the PIK3CD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.