This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for PIGO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,957,639–34,958,516 | 138.5 kb | Distal (>10kb) Multiome | 211 | |
| chr9:34,988,494–34,990,699 | 107.0 kb | Distal (>10kb) Multiome | 703 | |
| chr9:35,026,200–35,027,109 | 69.7 kb | Distal (>10kb) Multiome | 187 | |
| chr9:35,071,688–35,073,229 | 24.6 kb | Distal (>10kb) Multiome | 975 | |
| chr9:35,079,435–35,080,247 | 16.7 kb | Distal (>10kb) Multiome | 773 | |
| chr9:35,095,921–35,096,910 | 136 bp | At TSS Multiome | 960 | |
| chr9:35,102,684–35,103,800 | 6.7 kb | Proximal (<10kb) Multiome | 886 | |
| chr9:35,110,953–35,112,122 | 15.1 kb | Distal (>10kb) Multiome | 527 | |
| chr9:35,113,899–35,117,460 | 20.7 kb | Distal (>10kb) Multiome | 840 | |
| chr9:35,161,521–35,162,743 | 65.4 kb | Distal (>10kb) Multiome | 827 | |
| chr9:35,489,223–35,490,919 | 393.4 kb | Distal (>10kb) Multiome HiCAR | 918 |
Genomic view of the PIGO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.