This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIGH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,359,034–67,360,833 | 240.2 kb | Distal (>10kb) Multiome | 891 | |
| chr14:67,427,006–67,427,629 | 172.9 kb | Distal (>10kb) Multiome | 288 | |
| chr14:67,514,900–67,515,814 | 84.9 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,532,784–67,533,987 | 67.0 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 58.2 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 50 bp | At TSS Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 19.6 kb | Distal (>10kb) Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 74.5 kb | Distal (>10kb) Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 94.6 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 129.1 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 216.4 kb | Distal (>10kb) Multiome | 712 | |
| chr14:67,819,625–67,820,281 | 219.6 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the PIGH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.