Involved in regulation of endoplasmic reticulum unfolded protein response. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PIGBOS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGBOS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGBOS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,196,449–55,197,580 | 122.1 kb | Distal (>10kb) Multiome | 812 | |
| chr15:55,288,999–55,291,001 | 28.6 kb | Distal (>10kb) Multiome | 744 | |
| chr15:55,318,855–55,319,494 | 71 bp | At TSS Multiome | 875 | |
| chr15:55,394,084–55,395,667 | 75.9 kb | Distal (>10kb) Multiome | 153 | |
| chr15:55,407,568–55,409,007 | 89.2 kb | Distal (>10kb) Multiome | 957 | |
| chr15:55,498,088–55,498,593 | 179.3 kb | Distal (>10kb) Multiome | 637 | |
| chr15:55,587,537–55,588,889 | 269.2 kb | Distal (>10kb) Multiome | 432 |
Genomic view of the PIGBOS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.