This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for PIBF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIBF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIBF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:72,726,793–72,728,423 | 54.4 kb | Distal (>10kb) Multiome | 908 | |
| chr13:72,781,287–72,782,590 | 112 bp | At TSS Multiome | 793 | |
| chr13:73,039,002–73,040,203 | 257.7 kb | Distal (>10kb) Multiome | 182 | |
| chr13:73,058,366–73,060,121 | 276.8 kb | Distal (>10kb) Multiome | 776 | |
| chr13:73,765,465–73,766,384 | 983.9 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr13:73,767,698–73,768,912 | 986.1 kb | Distal (>10kb) Multiome HiCAR | 165 |
Genomic view of the PIBF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.