PI4K2A

phosphatidylinositol 4-kinase type 2 alpha | DKFZP761G1923, PI4KII, PIK42A

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Biological processes 54 terms

1-phosphatidylinositol 4-kinase activity (GO:0004430)1-phosphatidylinositol 4-kinase activity (GO:0004430)1-phosphatidylinositol 4-kinase activity (GO:0004430)1-phosphatidylinositol 4-kinase activity (GO:0004430)AP-3 adaptor complex binding (GO:0035651)AP-3 adaptor complex binding (GO:0035651)ATP binding (GO:0005524)BLOC-1 complex (GO:0031083)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi organization (GO:0007030)clathrin-sculpted vesicle (GO:0060198)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytosol (GO:0005829)dendrite (GO:0030425)dendrite (GO:0030425)early endosome membrane (GO:0031901)endosome (GO:0005768)endosome (GO:0005768)endosome (GO:0005768)endosome membrane (GO:0010008)endosome membrane (GO:0010008)endosome organization (GO:0007032)glutamatergic synapse (GO:0098978)growing cell tip (GO:0035838)lysosomal membrane (GO:0005765)magnesium ion binding (GO:0000287)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)membrane raft (GO:0045121)membrane raft (GO:0045121)mitochondrion (GO:0005739)mitochondrion (GO:0005739)neuron projection (GO:0043005)neuron projection (GO:0043005)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)perikaryon (GO:0043204)phosphatidylinositol biosynthetic process (GO:0006661)phosphatidylinositol biosynthetic process (GO:0006661)phosphatidylinositol phosphate biosynthetic process (GO:0046854)phosphatidylinositol phosphate biosynthetic process (GO:0046854)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)presynaptic active zone (GO:0048786)presynaptic membrane (GO:0042734)presynaptic membrane (GO:0042734)protein binding (GO:0005515)synapse (GO:0045202)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating PI4K2A 0 TFs

Transcription factors with Perturb-seq knockdown data for PI4K2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PI4K2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PI4K2A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PI4K2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:97,400,817–97,401,691	239.4 kb	Distal (>10kb) Multiome	644
chr10:97,407,246–97,407,739	233.2 kb	Distal (>10kb) Multiome	539
chr10:97,418,830–97,419,461	221.5 kb	Distal (>10kb) Multiome	323
chr10:97,425,050–97,426,796	214.5 kb	Distal (>10kb) Multiome	715
chr10:97,445,521–97,446,585	194.5 kb	Distal (>10kb) Multiome	802
chr10:97,497,718–97,499,773	142.0 kb	Distal (>10kb) Multiome	967
chr10:97,553,598–97,554,047	86.9 kb	Distal (>10kb) Multiome	340
chr10:97,632,775–97,633,915	7.2 kb	Proximal (<10kb) Multiome	725
chr10:97,640,236–97,641,335	53 bp	At TSS Multiome	712
chr10:97,686,724–97,687,987	46.7 kb	Distal (>10kb) Multiome	993
chr10:97,713,223–97,715,263	73.1 kb	Distal (>10kb) Multiome	639
chr10:97,736,595–97,737,824	96.4 kb	Distal (>10kb) Multiome	1009
chr10:97,771,123–97,772,389	131.1 kb	Distal (>10kb) Multiome	356
chr10:97,788,725–97,789,448	148.5 kb	Distal (>10kb) Multiome	398
chr10:97,849,566–97,850,474	209.4 kb	Distal (>10kb) Multiome	400
chr10:97,857,830–97,858,402	217.4 kb	Distal (>10kb) Multiome	160
chr10:97,869,190–97,869,924	228.9 kb	Distal (>10kb) Multiome	506

Genome Browser

Genomic view of the PI4K2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.