Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHYHIPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHYHIPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHYHIPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:58,963,557–58,964,156 | 213.4 kb | Distal (>10kb) Multiome HiCAR | 302 | |
| chr10:58,967,237–58,968,390 | 209.4 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr10:59,175,751–59,177,806 | 290 bp | At TSS Multiome | 837 | |
| chr10:59,181,583–59,182,150 | 4.3 kb | Proximal (<10kb) | 186 | |
| chr10:59,361,753–59,363,447 | 185.4 kb | Distal (>10kb) Multiome | 562 |
Genomic view of the PHYHIPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.