This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for PHPT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHPT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHPT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,572,053–136,572,865 | 277.1 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 261.1 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 222.5 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 183.6 kb | Distal (>10kb) Multiome | 409 | |
| chr9:136,686,875–136,688,079 | 161.9 kb | Distal (>10kb) Multiome | 610 | |
| chr9:136,711,795–136,713,743 | 137.0 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 121.2 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 86.2 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 60.1 kb | Distal (>10kb) Multiome | 351 | |
| chr9:136,790,433–136,792,285 | 58.3 kb | Distal (>10kb) Multiome HiCAR | 864 | |
| chr9:136,798,823–136,801,421 | 48.1 kb | Distal (>10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 41.5 kb | Distal (>10kb) Multiome | 714 | |
| chr9:136,840,460–136,841,401 | 8.0 kb | Proximal (<10kb) | 399 | |
| chr9:136,842,325–136,842,872 | 6.9 kb | Proximal (<10kb) Multiome | 492 | |
| chr9:136,843,849–136,845,157 | 4.2 kb | Proximal (<10kb) | 100 | |
| chr9:136,846,187–136,850,214 | 32 bp | At TSS Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 17.0 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 37.0 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 95.3 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 100.8 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 129.1 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 142.9 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 178.9 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 180.2 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 197.1 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 204.7 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 218.7 kb | Distal (>10kb) Multiome | 492 | |
| chr9:137,069,879–137,071,138 | 221.2 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 228.0 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 237.5 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,129,244–137,130,499 | 280.4 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the PHPT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.