Predicted to enable phosphatase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHOSPHO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHOSPHO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHOSPHO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:169,479,264–169,479,982 | 214.9 kb | Distal (>10kb) Multiome | 907 | |
| chr2:169,573,179–169,574,073 | 120.6 kb | Distal (>10kb) Multiome | 834 | |
| chr2:169,584,221–169,584,891 | 110.0 kb | Distal (>10kb) Multiome | 994 | |
| chr2:169,694,097–169,694,854 | 45 bp | At TSS Multiome | 898 | |
| chr2:169,733,252–169,734,532 | 39.5 kb | Distal (>10kb) Multiome | 735 | |
| chr2:169,789,706–169,790,238 | 95.5 kb | Distal (>10kb) Multiome | 539 | |
| chr2:169,798,658–169,799,453 | 104.5 kb | Distal (>10kb) Multiome | 794 | |
| chr2:169,824,413–169,825,252 | 130.5 kb | Distal (>10kb) Multiome | 946 | |
| chr2:169,827,076–169,828,199 | 133.0 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the PHOSPHO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.