Involved in regulation of embryonic development; regulation of epithelial to mesenchymal transition; and regulation of microtubule cytoskeleton organization. Located in basal cortex. Implicated in osteogenesis imperfecta. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PHLDB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHLDB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHLDB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,152,392–118,153,276 | 462.7 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr11:118,359,034–118,359,890 | 256.0 kb | Distal (>10kb) Multiome | 779 | |
| chr11:118,401,086–118,402,051 | 214.1 kb | Distal (>10kb) Multiome | 732 | |
| chr11:118,434,505–118,437,761 | 179.3 kb | Distal (>10kb) Multiome | 1053 | |
| chr11:118,530,432–118,531,848 | 84.5 kb | Distal (>10kb) Multiome | 763 | |
| chr11:118,571,906–118,572,919 | 43.2 kb | Distal (>10kb) Multiome | 760 | |
| chr11:118,607,481–118,608,230 | 7.4 kb | Proximal (<10kb) | 464 | |
| chr11:118,608,335–118,608,628 | 7.0 kb | Proximal (<10kb) | 456 | |
| chr11:118,610,391–118,611,672 | 4.3 kb | Proximal (<10kb) Multiome | 488 | |
| chr11:118,620,694–118,621,880 | 5.8 kb | Proximal (<10kb) Multiome | 683 | |
| chr11:118,634,418–118,635,567 | 19.5 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 44.1 kb | Distal (>10kb) Multiome | 459 | |
| chr11:118,689,268–118,690,813 | 74.5 kb | Distal (>10kb) Multiome | 804 | |
| chr11:118,714,768–118,715,435 | 99.3 kb | Distal (>10kb) Multiome | 87 | |
| chr11:118,715,577–118,717,605 | 101.7 kb | Distal (>10kb) Multiome | 445 | |
| chr11:118,789,603–118,790,362 | 174.2 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 177.4 kb | Distal (>10kb) Multiome | 958 | |
| chr11:118,907,074–118,907,685 | 291.7 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 293.8 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 295.0 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 296.7 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 301.4 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 302.8 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the PHLDB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.