Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHLDA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHLDA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHLDA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:201,170,516–201,172,002 | 298.3 kb | Distal (>10kb) Multiome | 988 | |
| chr1:201,259,443–201,260,371 | 209.4 kb | Distal (>10kb) Multiome | 253 | |
| chr1:201,283,211–201,283,740 | 185.7 kb | Distal (>10kb) Multiome | 190 | |
| chr1:201,347,882–201,348,374 | 121.1 kb | Distal (>10kb) Multiome | 172 | |
| chr1:201,376,377–201,377,141 | 92.4 kb | Distal (>10kb) Multiome | 281 | |
| chr1:201,399,066–201,399,918 | 69.7 kb | Distal (>10kb) Multiome | 592 | |
| chr1:201,408,123–201,408,690 | 60.8 kb | Distal (>10kb) Multiome | 297 | |
| chr1:201,448,161–201,448,846 | 20.8 kb | Distal (>10kb) Multiome | 392 | |
| chr1:201,468,360–201,469,993 | 39 bp | At TSS Multiome | 750 | |
| chr1:201,480,274–201,481,139 | 11.5 kb | Distal (>10kb) Multiome | 523 | |
| chr1:201,481,427–201,482,595 | 13.0 kb | Distal (>10kb) Multiome | 609 | |
| chr1:201,506,847–201,507,390 | 37.9 kb | Distal (>10kb) Multiome | 605 | |
| chr1:201,538,592–201,540,560 | 69.8 kb | Distal (>10kb) Multiome | 592 | |
| chr1:201,559,535–201,560,001 | 90.6 kb | Distal (>10kb) Multiome | 463 | |
| chr1:201,614,255–201,614,715 | 145.2 kb | Distal (>10kb) Multiome | 227 | |
| chr1:201,648,049–201,650,866 | 181.2 kb | Distal (>10kb) Multiome | 533 | |
| chr1:201,678,604–201,679,421 | 209.7 kb | Distal (>10kb) Multiome | 158 | |
| chr1:201,739,028–201,740,430 | 270.5 kb | Distal (>10kb) Multiome | 287 |
Genomic view of the PHLDA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.