This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for PHKG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHKG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHKG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:55,886,966–55,887,754 | 205.5 kb | Distal (>10kb) Multiome | 546 | |
| chr7:55,951,547–55,952,549 | 141.1 kb | Distal (>10kb) Multiome | 801 | |
| chr7:55,964,099–55,965,278 | 128.3 kb | Distal (>10kb) Multiome | 738 | |
| chr7:56,033,660–56,034,707 | 58.8 kb | Distal (>10kb) Multiome | 673 | |
| chr7:56,051,159–56,052,300 | 41.4 kb | Distal (>10kb) Multiome | 882 | |
| chr7:56,063,656–56,065,393 | 28.7 kb | Distal (>10kb) Multiome | 926 | |
| chr7:56,074,109–56,074,780 | 18.6 kb | Distal (>10kb) Multiome | 423 | |
| chr7:56,092,789–56,093,211 | at TSS | At TSS | 229 | |
| chr7:56,106,168–56,106,786 | 13.6 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the PHKG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.