Transcription factors with Perturb-seq knockdown data for PGLS-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGLS-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGLS-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,215,005–17,215,979 | 296.0 kb | Distal (>10kb) Multiome | 897 | |
| chr19:17,225,705–17,226,889 | 285.1 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,234,748–17,236,650 | 275.6 kb | Distal (>10kb) Multiome | 612 | |
| chr19:17,244,882–17,247,104 | 265.4 kb | Distal (>10kb) Multiome | 862 | |
| chr19:17,247,935–17,248,860 | 262.9 kb | Distal (>10kb) Multiome | 588 | |
| chr19:17,266,931–17,267,755 | 244.3 kb | Distal (>10kb) Multiome | 720 | |
| chr19:17,281,537–17,283,120 | 228.7 kb | Distal (>10kb) Multiome | 669 | |
| chr19:17,292,242–17,293,049 | 218.8 kb | Distal (>10kb) Multiome | 513 | |
| chr19:17,302,721–17,303,771 | 208.1 kb | Distal (>10kb) Multiome | 636 | |
| chr19:17,305,286–17,306,514 | 205.8 kb | Distal (>10kb) Multiome | 947 | |
| chr19:17,309,159–17,310,151 | 202.0 kb | Distal (>10kb) Multiome | 741 | |
| chr19:17,327,532–17,329,548 | 183.5 kb | Distal (>10kb) Multiome | 370 | |
| chr19:17,334,287–17,335,052 | 176.7 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,336,574–17,338,240 | 174.0 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,340,311–17,341,226 | 170.9 kb | Distal (>10kb) Multiome | 419 | |
| chr19:17,390,414–17,391,521 | 120.3 kb | Distal (>10kb) Multiome | 615 | |
| chr19:17,394,998–17,395,433 | 116.3 kb | Distal (>10kb) Multiome | 403 | |
| chr19:17,398,863–17,399,537 | 112.3 kb | Distal (>10kb) Multiome | 132 | |
| chr19:17,403,087–17,404,355 | 108.0 kb | Distal (>10kb) Multiome | 211 | |
| chr19:17,419,503–17,420,821 | 91.6 kb | Distal (>10kb) Multiome | 869 | |
| chr19:17,424,865–17,425,411 | 86.4 kb | Distal (>10kb) Multiome | 328 | |
| chr19:17,448,174–17,448,841 | 62.9 kb | Distal (>10kb) Multiome | 392 | |
| chr19:17,468,858–17,470,905 | 41.4 kb | Distal (>10kb) Multiome | 743 | |
| chr19:17,488,739–17,489,689 | 22.4 kb | Distal (>10kb) Multiome | 381 | |
| chr19:17,511,113–17,512,592 | 24 bp | At TSS Multiome | 1021 | |
| chr19:17,538,878–17,540,353 | 28.3 kb | Distal (>10kb) Multiome | 725 | |
| chr19:17,555,194–17,556,523 | 44.0 kb | Distal (>10kb) Multiome | 713 | |
| chr19:17,576,463–17,577,455 | 65.5 kb | Distal (>10kb) Multiome | 236 | |
| chr19:17,579,580–17,580,242 | 68.5 kb | Distal (>10kb) Multiome | 281 | |
| chr19:17,605,468–17,607,009 | 94.7 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:17,686,280–17,688,656 | 175.3 kb | Distal (>10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 208.0 kb | Distal (>10kb) Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 236.1 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 251.2 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 266.9 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 283.6 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 319.4 kb | Distal (>10kb) Multiome HiCAR | 466 |
Genomic view of the PGLS-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.