This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PFDN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PFDN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PFDN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:140,038,152–140,038,948 | 264.5 kb | Distal (>10kb) Multiome | 241 | |
| chr5:140,042,572–140,043,835 | 259.8 kb | Distal (>10kb) Multiome | 523 | |
| chr5:140,107,138–140,108,849 | 195.2 kb | Distal (>10kb) Multiome | 993 | |
| chr5:140,112,921–140,114,941 | 189.0 kb | Distal (>10kb) Multiome | 811 | |
| chr5:140,145,842–140,146,580 | 157.0 kb | Distal (>10kb) Multiome | 366 | |
| chr5:140,157,178–140,157,756 | 145.7 kb | Distal (>10kb) Multiome | 504 | |
| chr5:140,174,682–140,176,221 | 128.0 kb | Distal (>10kb) Multiome | 959 | |
| chr5:140,302,631–140,303,538 | 56 bp | At TSS Multiome | 552 | |
| chr5:140,345,869–140,347,147 | 43.6 kb | Distal (>10kb) Multiome | 671 | |
| chr5:140,363,055–140,363,697 | 60.3 kb | Distal (>10kb) Multiome | 542 | |
| chr5:140,372,779–140,373,538 | 70.1 kb | Distal (>10kb) Multiome | 302 | |
| chr5:140,400,395–140,402,925 | 98.5 kb | Distal (>10kb) Multiome | 1129 | |
| chr5:140,546,917–140,548,500 | 244.6 kb | Distal (>10kb) Multiome | 784 | |
| chr5:140,556,971–140,557,959 | 254.4 kb | Distal (>10kb) Multiome | 886 | |
| chr5:140,564,055–140,565,123 | 261.5 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the PFDN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.