The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PEX11G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX11G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX11G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,199,134–6,200,121 | 1289.3 kb | Distal (>10kb) Multiome HiCAR | 769 | |
| chr19:6,515,952–6,517,331 | 972.8 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr19:7,197,125–7,197,557 | 291.8 kb | Distal (>10kb) Multiome | 652 | |
| chr19:7,197,811–7,198,607 | 290.8 kb | Distal (>10kb) Multiome | 815 | |
| chr19:7,293,755–7,294,636 | 194.6 kb | Distal (>10kb) Multiome | 668 | |
| chr19:7,394,774–7,395,629 | 94.0 kb | Distal (>10kb) Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 5.5 kb | Proximal (<10kb) | 201 | |
| chr19:7,488,712–7,489,463 | 20 bp | At TSS Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 12.1 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 17.5 kb | Distal (>10kb) Multiome | 516 | |
| chr19:7,522,263–7,523,208 | 33.5 kb | Distal (>10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 45.0 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 62.3 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 66.3 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 106.8 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 140.6 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 148.0 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 191.7 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the PEX11G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.