This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for PEX11A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX11A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX11A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,399,210–89,400,654 | 290.9 kb | Distal (>10kb) Multiome | 464 | |
| chr15:89,407,314–89,408,300 | 282.8 kb | Distal (>10kb) Multiome | 207 | |
| chr15:89,411,338–89,411,946 | 279.1 kb | Distal (>10kb) Multiome | 362 | |
| chr15:89,416,314–89,416,831 | 274.2 kb | Distal (>10kb) Multiome | 411 | |
| chr15:89,430,551–89,431,192 | 259.9 kb | Distal (>10kb) Multiome | 520 | |
| chr15:89,496,217–89,496,744 | 194.3 kb | Distal (>10kb) Multiome | 337 | |
| chr15:89,575,079–89,576,170 | 115.4 kb | Distal (>10kb) Multiome | 805 | |
| chr15:89,654,859–89,655,986 | 35.3 kb | Distal (>10kb) Multiome | 484 | |
| chr15:89,665,508–89,666,065 | 25.0 kb | Distal (>10kb) Multiome | 279 | |
| chr15:89,690,263–89,691,125 | 24 bp | At TSS Multiome | 669 | |
| chr15:89,747,326–89,748,774 | 57.3 kb | Distal (>10kb) Multiome | 214 | |
| chr15:89,750,169–89,751,978 | 60.2 kb | Distal (>10kb) Multiome | 732 | |
| chr15:89,760,201–89,761,182 | 70.0 kb | Distal (>10kb) Multiome | 473 | |
| chr15:89,775,879–89,777,425 | 85.9 kb | Distal (>10kb) Multiome | 647 | |
| chr15:89,893,669–89,894,442 | 203.3 kb | Distal (>10kb) Multiome | 1083 | |
| chr15:89,912,261–89,913,121 | 222.1 kb | Distal (>10kb) Multiome | 514 |
Genomic view of the PEX11A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.