PEX10

peroxisomal biogenesis factor 10 | RNF69

This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Biological processes 27 terms

cellular response to reactive oxygen species (GO:0034614)peroxisomal membrane (GO:0005778)peroxisomal membrane (GO:0005778)peroxisomal membrane (GO:0005778)peroxisomal membrane (GO:0005778)peroxisomal membrane (GO:0005778)peroxisomal membrane (GO:0005778)peroxisome (GO:0005777)peroxisome organization (GO:0007031)peroxisome organization (GO:0007031)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein import into peroxisome matrix (GO:0016558)protein import into peroxisome matrix (GO:0016558)protein import into peroxisome matrix (GO:0016558)protein import into peroxisome matrix (GO:0016558)protein import into peroxisome matrix (GO:0016558)protein import into peroxisome matrix, receptor recycling (GO:0016562)protein import into peroxisome matrix, substrate release (GO:0044721)protein polyubiquitination (GO:0000209)protein quality control for misfolded or incompletely synthesized proteins (GO:0006515)protein ubiquitination (GO:0016567)transmembrane protein transporter activity (GO:0008320)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating PEX10 0 TFs

Transcription factors with Perturb-seq knockdown data for PEX10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PEX10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:2,132,340–2,134,100	279.1 kb	Distal (>10kb) Multiome	508
chr1:2,189,382–2,190,314	222.9 kb	Distal (>10kb) Multiome	719
chr1:2,194,502–2,195,788	217.5 kb	Distal (>10kb) Multiome	789
chr1:2,199,148–2,199,756	213.1 kb	Distal (>10kb) Multiome	445
chr1:2,204,191–2,206,396	207.4 kb	Distal (>10kb) Multiome	597
chr1:2,212,255–2,213,305	199.9 kb	Distal (>10kb) Multiome	601
chr1:2,226,557–2,228,163	184.7 kb	Distal (>10kb) Multiome	675
chr1:2,248,086–2,248,655	164.1 kb	Distal (>10kb) Multiome	296
chr1:2,279,142–2,279,636	133.1 kb	Distal (>10kb) Multiome	172
chr1:2,311,328–2,311,918	100.9 kb	Distal (>10kb) Multiome	366
chr1:2,314,340–2,315,728	97.5 kb	Distal (>10kb) Multiome	557
chr1:2,391,076–2,392,400	20.9 kb	Distal (>10kb) Multiome	820
chr1:2,411,953–2,414,836	96 bp	At TSS Multiome	918
chr1:2,525,908–2,527,142	113.9 kb	Distal (>10kb) Multiome HiCAR	668
chr1:2,529,108–2,529,820	116.7 kb	Distal (>10kb) Multiome HiCAR	222
chr1:2,545,676–2,548,580	135.7 kb	Distal (>10kb) Multiome HiCAR	918
chr1:2,585,182–2,587,696	174.1 kb	Distal (>10kb) Multiome	748
chr1:2,642,358–2,643,801	230.7 kb	Distal (>10kb) Multiome	706
chr1:3,453,034–3,455,700	1042.2 kb	Distal (>10kb) Multiome HiCAR	874
chr1:3,530,504–3,532,073	1118.9 kb	Distal (>10kb) Multiome HiCAR	442

Genome Browser

Genomic view of the PEX10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.