Predicted to enable protein-macromolecule adaptor activity. Involved in pore complex assembly. Located in basolateral plasma membrane and cytosol. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDZD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDZD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDZD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:69,990,216–69,990,702 | 299.4 kb | Distal (>10kb) Multiome | 49 | |
| chrX:70,133,101–70,133,613 | 156.3 kb | Distal (>10kb) Multiome | 529 | |
| chrX:70,289,676–70,290,592 | 129 bp | At TSS Multiome | 481 | |
| chrX:70,433,669–70,435,047 | 144.6 kb | Distal (>10kb) Multiome | 638 | |
| chrX:70,452,116–70,452,807 | 162.5 kb | Distal (>10kb) Multiome | 254 | |
| chrX:70,454,439–70,455,911 | 165.0 kb | Distal (>10kb) Multiome | 546 | |
| chrX:70,508,261–70,509,156 | 218.7 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the PDZD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.