Predicted to enable unfolded protein binding activity. Predicted to be involved in protein stabilization. Part of RPAP3/R2TP/prefoldin-like complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:31,661,610–31,662,406 | 290.3 kb | Distal (>10kb) Multiome | 836 | |
| chr20:31,693,987–31,694,929 | 257.7 kb | Distal (>10kb) Multiome | 357 | |
| chr20:31,722,556–31,724,276 | 228.4 kb | Distal (>10kb) Multiome | 1147 | |
| chr20:31,738,777–31,739,576 | 212.8 kb | Distal (>10kb) Multiome | 923 | |
| chr20:31,822,496–31,823,111 | 129.1 kb | Distal (>10kb) Multiome | 479 | |
| chr20:31,860,463–31,862,362 | 90.3 kb | Distal (>10kb) Multiome | 627 | |
| chr20:31,870,005–31,870,863 | 81.6 kb | Distal (>10kb) Multiome | 460 | |
| chr20:31,879,388–31,880,438 | 72.2 kb | Distal (>10kb) Multiome | 900 | |
| chr20:31,951,523–31,952,606 | 12 bp | At TSS Multiome | 879 | |
| chr20:31,967,880–31,968,893 | 16.4 kb | Distal (>10kb) Multiome | 1059 | |
| chr20:31,972,125–31,972,938 | 20.4 kb | Distal (>10kb) Multiome | 252 | |
| chr20:32,017,795–32,019,711 | 66.3 kb | Distal (>10kb) Multiome | 611 | |
| chr20:32,031,048–32,031,781 | 79.5 kb | Distal (>10kb) Multiome | 627 | |
| chr20:32,109,321–32,110,237 | 157.7 kb | Distal (>10kb) Multiome | 1073 | |
| chr20:32,189,679–32,190,832 | 238.3 kb | Distal (>10kb) Multiome | 290 | |
| chr20:32,207,261–32,208,118 | 255.7 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the PDRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.