This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for PDP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,603,736–66,605,778 | 275.9 kb | Distal (>10kb) Multiome | 907 | |
| chr16:66,608,358–66,609,044 | 271.9 kb | Distal (>10kb) Multiome | 698 | |
| chr16:66,616,501–66,617,327 | 263.7 kb | Distal (>10kb) Multiome | 204 | |
| chr16:66,695,775–66,697,411 | 183.7 kb | Distal (>10kb) Multiome | 714 | |
| chr16:66,751,110–66,752,176 | 128.8 kb | Distal (>10kb) Multiome | 734 | |
| chr16:66,830,425–66,831,324 | 49.6 kb | Distal (>10kb) Multiome | 934 | |
| chr16:66,844,097–66,844,861 | 36.1 kb | Distal (>10kb) Multiome | 211 | |
| chr16:66,872,965–66,873,714 | 7.3 kb | Proximal (<10kb) Multiome | 836 | |
| chr16:66,880,003–66,881,270 | 50 bp | At TSS Multiome | 1020 | |
| chr16:66,924,739–66,925,515 | 44.5 kb | Distal (>10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 53.9 kb | Distal (>10kb) Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 120.5 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 133.6 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 137.5 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 148.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 229.3 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 270.2 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 274.9 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 280.5 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 282.9 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 289.0 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 293.8 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 297.7 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the PDP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.