Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDCL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:122,092,682–122,093,762 | 735.2 kb | Distal (>10kb) Multiome HiCAR | 771 | |
| chr9:122,099,169–122,100,386 | 728.8 kb | Distal (>10kb) Multiome HiCAR | 262 | |
| chr9:122,159,157–122,160,157 | 668.8 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr9:122,562,159–122,562,684 | 266.3 kb | Distal (>10kb) Multiome | 32 | |
| chr9:122,827,785–122,828,901 | 96 bp | At TSS Multiome | 765 | |
| chr9:122,904,531–122,905,694 | 76.8 kb | Distal (>10kb) Multiome | 890 | |
| chr9:122,912,955–122,913,476 | 84.7 kb | Distal (>10kb) Multiome | 779 | |
| chr9:122,930,976–122,932,127 | 102.9 kb | Distal (>10kb) Multiome | 857 | |
| chr9:122,940,508–122,941,931 | 112.4 kb | Distal (>10kb) Multiome | 767 | |
| chr9:123,353,960–123,354,559 | 525.6 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr9:123,359,538–123,361,097 | 531.8 kb | Distal (>10kb) Multiome HiCAR | 570 |
Genomic view of the PDCL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.