Transcription factors with Perturb-seq knockdown data for PDCD6IP-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCD6IP-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCD6IP-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:33,789,231–33,789,619 | 8.9 kb | Proximal (<10kb) | 49 | |
| chr3:33,794,588–33,794,760 | 3.8 kb | Proximal (<10kb) | 2 | |
| chr3:33,798,073–33,799,435 | at TSS | At TSS | 1044 | |
| chr3:33,804,156–33,804,537 | 5.6 kb | Proximal (<10kb) | 71 |
Genomic view of the PDCD6IP-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.