The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for PCSK1N. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCSK1N upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCSK1N, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,539,185–48,540,294 | 296.0 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 261.1 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 237.7 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 159.1 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 138.9 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 98.2 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 33.7 kb | Distal (>10kb) Multiome | 734 | |
| chrX:48,891,080–48,891,988 | 56.1 kb | Distal (>10kb) Multiome | 525 | |
| chrX:48,897,163–48,898,345 | 62.3 kb | Distal (>10kb) Multiome | 672 | |
| chrX:48,911,574–48,912,414 | 76.3 kb | Distal (>10kb) Multiome | 671 | |
| chrX:48,917,179–48,917,999 | 81.8 kb | Distal (>10kb) Multiome | 468 | |
| chrX:48,918,412–48,919,792 | 83.6 kb | Distal (>10kb) Multiome | 693 | |
| chrX:48,957,469–48,959,105 | 122.7 kb | Distal (>10kb) Multiome | 722 | |
| chrX:49,001,538–49,002,676 | 166.7 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 204.5 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 208.0 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 218.0 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 236.5 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 238.5 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,100,885–49,101,855 | 265.7 kb | Distal (>10kb) Multiome | 562 |
Genomic view of the PCSK1N locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.