Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PCOLCE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCOLCE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCOLCE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,335,652–100,336,470 | 268.3 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 222.4 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 175.5 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 167.9 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 153.7 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 125.0 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 120.8 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 65.4 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 61.8 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 34.8 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 18.0 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,603,662–100,605,927 | 1.3 kb | Proximal (<10kb) | 628 | |
| chr7:100,611,685–100,612,981 | 7.8 kb | Proximal (<10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 22.3 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 52.0 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 69.1 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 71.5 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 87.4 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 89.9 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 101.5 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 223.2 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 232.3 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 248.0 kb | Distal (>10kb) Multiome | 805 | |
| chr7:100,874,652–100,875,664 | 270.6 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 285.4 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 291.6 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 292.7 kb | Distal (>10kb) Multiome | 538 |
Genomic view of the PCOLCE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.