The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PCGF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCGF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCGF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,192,518–103,193,861 | 157.9 kb | Distal (>10kb) Multiome | 725 | |
| chr10:103,204,930–103,206,025 | 146.1 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,206,729–103,207,578 | 143.9 kb | Distal (>10kb) Multiome | 46 | |
| chr10:103,276,757–103,278,251 | 73.8 kb | Distal (>10kb) Multiome | 385 | |
| chr10:103,350,520–103,351,294 | 110 bp | At TSS Multiome | 679 | |
| chr10:103,367,765–103,368,860 | 17.5 kb | Distal (>10kb) Multiome | 925 | |
| chr10:103,395,952–103,396,926 | 45.4 kb | Distal (>10kb) Multiome | 821 | |
| chr10:103,493,310–103,494,526 | 142.5 kb | Distal (>10kb) Multiome | 299 | |
| chr10:103,542,810–103,543,379 | 192.0 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the PCGF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.