Enables identical protein binding activity. Involved in maintenance of gastrointestinal epithelium. Acts upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PBLD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PBLD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PBLD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,074,303–68,075,534 | 257.8 kb | Distal (>10kb) Multiome | 860 | |
| chr10:68,231,028–68,232,253 | 101.4 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr10:68,271,165–68,272,025 | 61.3 kb | Distal (>10kb) Multiome | 177 | |
| chr10:68,331,343–68,333,064 | 75 bp | At TSS Multiome | 1174 | |
| chr10:68,406,245–68,407,662 | 74.3 kb | Distal (>10kb) Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 139.0 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 194.6 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 227.4 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 267.5 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the PBLD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.