This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for PASK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PASK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PASK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,902,359–240,903,515 | 247.4 kb | Distal (>10kb) Multiome | 217 | |
| chr2:240,997,873–240,999,416 | 151.8 kb | Distal (>10kb) Multiome | 439 | |
| chr2:241,009,658–241,010,603 | 140.2 kb | Distal (>10kb) Multiome | 314 | |
| chr2:241,102,057–241,102,727 | 47.9 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 868 bp | At TSS Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 67.5 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 122.5 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 165.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 204.8 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 205.9 kb | Distal (>10kb) Multiome | 680 |
Genomic view of the PASK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.